diff --git a/worlds/jakanddaxter/agents/memory_reader.py b/worlds/jakanddaxter/agents/memory_reader.py
index 493fbde39e4..9b39f18dcb9 100644
--- a/worlds/jakanddaxter/agents/memory_reader.py
+++ b/worlds/jakanddaxter/agents/memory_reader.py
@@ -4,7 +4,8 @@ import struct
 import sys
 from typing import ByteString, Callable
 import json
-from PyMemoryEditor import OpenProcess, ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess
+from PyMemoryEditor import OpenProcess, PyMemoryEditorError
+
 from dataclasses import dataclass
 
 import Utils
@@ -228,10 +229,8 @@ class JakAndDaxterMemoryReader:
 
         if self.connected:
             try:
-                # TODO - When PyMemoryEditor issue #15 is resolved, swap out this line for the commented one.
-                # self.gk_process.read_process_memory(0, bytes, 1)  # Ping to see if it's alive.
-                OpenProcess(process_name=jak1_gk)
-            except (ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess):
+                OpenProcess(name=jak1_gk)  # Ping to see if it's alive.
+            except PyMemoryEditorError as e:
                 msg = (f"Error reading game memory! (Did the game crash?)\n"
                        f"Please close all open windows and reopen the Jak and Daxter Client "
                        f"from the Archipelago Launcher.\n"
@@ -241,6 +240,7 @@ class JakAndDaxterMemoryReader:
                        f"   Then click Advanced > Open REPL.\n"
                        f"   Then close and reopen the Jak and Daxter Client from the Archipelago Launcher.")
                 self.log_error(logger, msg)
+                logger.error(e)
                 self.connected = False
         else:
             return
@@ -275,10 +275,11 @@ class JakAndDaxterMemoryReader:
 
     async def connect(self):
         try:
-            self.gk_process = OpenProcess(process_name=jak1_gk)  # The GOAL Kernel
+            self.gk_process = OpenProcess(name=jak1_gk)  # The GOAL Kernel
             logger.debug(f"Found the gk process: {self.gk_process.pid}")
-        except ProcessNotFoundError:
+        except PyMemoryEditorError as e:
             self.log_error(logger, "Could not find the game process.")
+            logger.error(e)
             self.connected = False
             return
 
@@ -320,7 +321,7 @@ class JakAndDaxterMemoryReader:
                 self.connected = True
             else:
                 raise Exception(memory_version_offset, sizeof_uint32)
-        except (ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess, Exception):
+        except Exception as e:
             if memory_version is None:
                 msg = (f"Could not find a version number in the OpenGOAL memory structure!\n"
                        f"   Expected Version: {str(expected_memory_version)}\n"
@@ -343,6 +344,7 @@ class JakAndDaxterMemoryReader:
                        f"   Click Versions and verify the latest version is marked 'Active'.\n"
                        f"   Close all launchers, games, clients, and console windows, then restart Archipelago.")
             self.log_error(logger, msg)
+            logger.error(e)
             self.connected = False
 
     async def print_status(self):
@@ -461,7 +463,7 @@ class JakAndDaxterMemoryReader:
                 self.finished_game = True
                 self.log_success(logger, "Congratulations! You finished the game!")
 
-        except (ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess):
+        except (PyMemoryEditorError, OSError) as e:
             msg = (f"Error reading game memory! (Did the game crash?)\n"
                    f"Please close all open windows and reopen the Jak and Daxter Client "
                    f"from the Archipelago Launcher.\n"
@@ -471,6 +473,7 @@ class JakAndDaxterMemoryReader:
                    f"   Then click Advanced > Open REPL.\n"
                    f"   Then close and reopen the Jak and Daxter Client from the Archipelago Launcher.")
             self.log_error(logger, msg)
+            logger.error(e)
             self.connected = False
 
         return self.location_outbox
diff --git a/worlds/jakanddaxter/agents/repl_client.py b/worlds/jakanddaxter/agents/repl_client.py
index 2a624d7f742..73f7a10bfbd 100644
--- a/worlds/jakanddaxter/agents/repl_client.py
+++ b/worlds/jakanddaxter/agents/repl_client.py
@@ -8,7 +8,7 @@ from dataclasses import dataclass
 from queue import Queue
 from typing import Callable
 
-from PyMemoryEditor import OpenProcess, ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess
+from PyMemoryEditor import OpenProcess, PyMemoryEditorError
 
 import asyncio
 from asyncio import StreamReader, StreamWriter, Lock
@@ -65,8 +65,8 @@ class JakAndDaxterReplClient:
 
     # The REPL client needs the REPL/compiler process running, but that process
     # also needs the game running. Therefore, the REPL client needs both running.
-    gk_process: OpenProcess = None
-    goalc_process: OpenProcess = None
+    gk_process: OpenProcess | None = None
+    goalc_process: OpenProcess | None = None
 
     item_inbox: dict[int, NetworkItem] = {}
     inbox_index = 0
@@ -101,10 +101,8 @@ class JakAndDaxterReplClient:
 
         if self.connected:
             try:
-                # TODO - When PyMemoryEditor issue #15 is resolved, swap out this line for the commented one.
-                # self.gk_process.read_process_memory(0, bytes, 1)  # Ping to see if it's alive.
-                OpenProcess(process_name=jak1_gk)
-            except (ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess):
+                OpenProcess(name=jak1_gk)
+            except PyMemoryEditorError as e:
                 msg = (f"Error reading game memory! (Did the game crash?)\n"
                        f"Please close all open windows and reopen the Jak and Daxter Client "
                        f"from the Archipelago Launcher.\n"
@@ -114,12 +112,11 @@ class JakAndDaxterReplClient:
                        f"   Then click Advanced > Open REPL.\n"
                        f"   Then close and reopen the Jak and Daxter Client from the Archipelago Launcher.")
                 self.log_error(logger, msg)
+                logger.error(e)
                 self.connected = False
             try:
-                # TODO - When PyMemoryEditor issue #15 is resolved, swap out this line for the commented one.
-                # self.goalc_process.read_process_memory(0, bytes, 1)  # Ping to see if it's alive.
-                OpenProcess(process_name=jak1_goalc)
-            except (ProcessNotFoundError, ProcessIDNotExistsError, ClosedProcess):
+                OpenProcess(name=jak1_goalc)
+            except PyMemoryEditorError as e:
                 msg = (f"Error sending data to compiler! (Did the compiler crash?)\n"
                        f"Please close all open windows and reopen the Jak and Daxter Client "
                        f"from the Archipelago Launcher.\n"
@@ -129,6 +126,7 @@ class JakAndDaxterReplClient:
                        f"   Then click Advanced > Open REPL.\n"
                        f"   Then close and reopen the Jak and Daxter Client from the Archipelago Launcher.")
                 self.log_error(logger, msg)
+                logger.error(e)
                 self.connected = False
         else:
             return
@@ -180,17 +178,19 @@ class JakAndDaxterReplClient:
 
     async def connect(self):
         try:
-            self.gk_process = OpenProcess(process_name=jak1_gk)  # The GOAL Kernel
+            self.gk_process = OpenProcess(name=jak1_gk)  # The GOAL Kernel
             logger.debug("Found the gk process: " + str(self.gk_process.pid))
-        except ProcessNotFoundError:
+        except PyMemoryEditorError as e:
             self.log_error(logger, "Could not find the game process.")
+            logger.error(e)
             return
 
         try:
-            self.goalc_process = OpenProcess(process_name=jak1_goalc)  # The GOAL Compiler and REPL
+            self.goalc_process = OpenProcess(name=jak1_goalc)  # The GOAL Compiler and REPL
             logger.debug("Found the goalc process: " + str(self.goalc_process.pid))
-        except ProcessNotFoundError:
+        except PyMemoryEditorError as e:
             self.log_error(logger, "Could not find the compiler process.")
+            logger.error(e)
             return
 
         try:
diff --git a/worlds/jakanddaxter/client.py b/worlds/jakanddaxter/client.py
index 710e0ef89d9..b76e6e70f79 100644
--- a/worlds/jakanddaxter/client.py
+++ b/worlds/jakanddaxter/client.py
@@ -22,7 +22,7 @@ import ModuleUpdate
 import Utils
 from CommonClient import ClientCommandProcessor, CommonContext, server_loop, gui_enabled
 from NetUtils import ClientStatus
-from PyMemoryEditor import OpenProcess, ProcessNotFoundError
+from PyMemoryEditor import OpenProcess, ProcessNotFoundError, AmbiguousProcessNameError
 
 # Jak imports
 from .game_id import jak1_name, jak1_gk, jak1_goalc
@@ -471,17 +471,25 @@ async def run_game(ctx: JakAndDaxterContext):
     # These may already be running. If they are not running, try to start them.
     gk_running = False
     try:
-        OpenProcess(process_name=jak1_gk)  # The GOAL Kernel
+        OpenProcess(name=jak1_gk)  # The GOAL Kernel
         gk_running = True
     except ProcessNotFoundError:
         ctx.on_log_warn(logger, "Game not running, attempting to start.")
+    except AmbiguousProcessNameError:
+        ctx.on_log_error(logger, "Two or more instances of the game were found. "
+                                 "Please close one and restart this client.")
+        return
 
     goalc_running = False
     try:
-        OpenProcess(process_name=jak1_goalc)  # The GOAL Compiler and REPL
+        OpenProcess(name=jak1_goalc)  # The GOAL Compiler and REPL
         goalc_running = True
     except ProcessNotFoundError:
         ctx.on_log_warn(logger, "Compiler not running, attempting to start.")
+    except AmbiguousProcessNameError:
+        ctx.on_log_error(logger, "Two or more instances of the compiler were found. "
+                                 "Please close one and restart this client.")
+        return
 
     try:
         auto_detect_root_directory = JakAndDaxterWorld.settings.auto_detect_root_directory
diff --git a/worlds/jakanddaxter/requirements.txt b/worlds/jakanddaxter/requirements.txt
index 9ec60e8d107..5a5f9919318 100644
--- a/worlds/jakanddaxter/requirements.txt
+++ b/worlds/jakanddaxter/requirements.txt
@@ -1 +1 @@
-PyMemoryEditor>=1.6.0
+PyMemoryEditor>=2.0.1